Morphometric parameters of pelvic lymph nodes in experimental metastatic prostate cancer

The study purpose. Identification of structural and functional changes in pelvic lymph nodes experimental metastatic prostate cancer. Materials methods. included 30 male mice aged 3 months. All animals ( n = 30) were divided into 2 groups. first group (the main one, 20) that had a model cancer created by transplanting an Ehrlich tumor the parenchyma. These further two equal subgroups: 1a 10) – withdrawn from experiment on day 7; 1b 18. second not manipulated, they made up control group. After end experiment, morphological analysis gland regional (pelvic) both groups was performed using light microscopy. Statistical processing results carried out Statistica 8.0 software package. differences considered statistically significant at p < 0.05. Results. When compared to 1b, parenchyma almost completely replaced atypical cells, which demonstrates presence neoplastic processes gland. In mice, number 1.9 times as large, animals, this indicator 2.7 higher 0.01). group, proportion mast cells increased 121 % At same time, we revealed direct relationship with immunoblasts medullar sinuses, indicates participation tissue basophils metastasis. We also recorded increase area sinuses 12.4 0.05) 20.2 0.01) against background zone possible lymphangiogenesis. Conclusion. Mast can potentially play role development malignant neoplasms increases obtained dependence suggests spread metastases. It be assumed infiltration may correlate poor prognosis cancer, since these granulocytes contribute